mouse NMNAT1 shRNA silencing AAV

Cat. No: shAAV-265880

Availability: 4-5 weeks

Name: AAV-m-NMNAT1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Nmnat1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Nmnat1
Gene Name: nicotinamide nucleotide adenylyltransferase 1
Gene ID: 66454
Gene Synonyms: 2610529L11Rik; 5730441G13Rik; D4Cole1e; nmnat
ORF Size: 858 bp
RefSeq#: NM_133435
Gene Description: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults.
UniGene ID: Mm.76062