mouse NFKBIA shRNA silencing AAV

Cat. No: shAAV-265725

Availability: 6-8 weeks

Name: AAV-m-NFKBIA-shRNA

This is an AAV expressing shRNA for silencing of Mouse Nfkbia.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Nfkbia
Gene Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
Gene ID: 18035
Gene Synonyms: AI462015; Nfkbi
ORF Size: 945 bp
RefSeq#: NM_010907
Gene Description: Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
UniGene ID: Mm.170515