mouse NDST1 shRNA silencing AAV

Cat. No: shAAV-265553

Availability: 4-5 weeks

Name: AAV-m-NDST1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Ndst1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Ndst1
Gene Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
Gene ID: 15531
Gene Synonyms: 1200015G06Rik; b2b2230Clo; Hsst; NDST-1
ORF Size: 2649 bp
RefSeq#: NM_008306
Gene Description: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response.
UniGene ID: Mm.181862