mouse MRGPRX1 shRNA silencing AAV

Cat. No: shAAV-264893

Availability: 6-8 weeks

Name: AAV-m-MRGPRX1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Mrgprx1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Mrgprx1
Gene Name: MAS-related GPR, member X1
Gene ID: 404242
Gene Synonyms: MrgC11; Mrgprc11
ORF Size: 972 bp
RefSeq#: NM_207540
Gene Description: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in an histamine-independent manner.
UniGene ID: Mm.354955