mouse MPZL1 shRNA silencing AAV

Cat. No: shAAV-264860

Availability: 4-5 weeks

Name: AAV-m-MPZL1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Mpzl1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Mpzl1
Gene Name: myelin protein zero-like 1
Gene ID: 68481
Gene Synonyms: 1110007A10Rik; PZR
ORF Size: 630 bp
RefSeq#: NM_001001880
Gene Description: Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.
UniGene ID: Mm.46438