mouse MLF1 shRNA silencing AAV

Cat. No: shAAV-264686

Availability: 4-5 weeks

Name: AAV-m-MLF1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Mlf1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Mlf1
Gene Name: myeloid leukemia factor 1
Gene ID: 17349
Gene Synonyms: HLS7
ORF Size: 849 bp
RefSeq#: NM_010801
Gene Description: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
UniGene ID: Mm.10414