mouse MBNL2 shRNA silencing AAV

Cat. No: shAAV-264325

Availability: 4-5 weeks

Name: AAV-m-MBNL2-shRNA

This is an AAV expressing shRNA for silencing of Mouse Mbnl2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Mbnl2
Gene Name: muscleblind-like 2
Gene ID: 105559
Gene Synonyms: 1110002M11Rik; AI047808; AI837313; AI849185; AL118326; MBLL; mKIAA4072; R75232
ORF Size: 1122 bp
RefSeq#: NM_207515
Gene Description: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulates expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM).
UniGene ID: Mm.400294