mouse MAP3K8 shRNA silencing AAV

Cat. No: shAAV-264198

Availability: 6-8 weeks

Name: AAV-m-MAP3K8-shRNA

This is an AAV expressing shRNA for silencing of Mouse Map3k8.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Map3k8
Gene Name: mitogen-activated protein kinase kinase kinase 8
Gene ID: 26410
Gene Synonyms: c-COT; Cot; Cot/Tpl2; Est; Estf; Tpl-2; Tpl2
ORF Size: 1404 bp
RefSeq#: NM_007746
Gene Description: Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.
UniGene ID: Mm.3275