mouse MAD2L2 shRNA silencing AAV

Cat. No: shAAV-264071

Availability: 4-5 weeks

Name: AAV-m-MAD2L2-shRNA

This is an AAV expressing shRNA for silencing of Mouse Mad2l2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Mad2l2
Gene Name: MAD2 mitotic arrest deficient-like 2
Gene ID: 71890
Gene Synonyms: 2310033C13Rik; G1-453-4; MAD2B; repro22; REV7
ORF Size: 636 bp
RefSeq#: NM_027985
Gene Description: Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.
UniGene ID: Mm.9648