mouse MAD1L1 shRNA silencing AAV

Cat. No: shAAV-264068

Availability: 4-5 weeks

Name: AAV-m-MAD1L1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Mad1l1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Mad1l1
Gene Name: MAD1 mitotic arrest deficient 1-like 1
Gene ID: 17120
Gene Synonyms: AI173502; AW550425; Mad1
ORF Size: 2154 bp
RefSeq#: NM_010752
Gene Description: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.
UniGene ID: Mm.27250