mouse MACROD1 shRNA silencing AAV

Cat. No: shAAV-264067

Availability: 4-5 weeks

Name: AAV-m-MACROD1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Macrod1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Macrod1
Gene Name: MACRO domain containing 1
Gene ID: 107227
Gene Synonyms: AI604841; AW743046; D930010J01Rik; Lrp16
ORF Size: 732 bp
RefSeq#: NM_134147
Gene Description: Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.
UniGene ID: Mm.439977