mouse LIG4 shRNA silencing AAV

Cat. No: shAAV-263448

Availability: 6-8 weeks

Name: AAV-m-LIG4-shRNA

This is an AAV expressing shRNA for silencing of Mouse Lig4.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Lig4
Gene Name: ligase IV, DNA, ATP-dependent
Gene ID: 319583
Gene Synonyms: 5830471N16Rik; tiny
ORF Size: 2733 bp
RefSeq#: NM_176953
Gene Description: Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
UniGene ID: Mm.80584