mouse KLHL21 shRNA silencing AAV

Cat. No: shAAV-262907

Availability: 4-5 weeks

Name: AAV-m-KLHL21-shRNA

This is an AAV expressing shRNA for silencing of Mouse Klhl21.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Klhl21
Gene Name: kelch-like 21
Gene ID: 242785
Gene Synonyms: 1810045K06Rik; D330008A20; mKIAA0469
ORF Size: 1794 bp
RefSeq#: NM_001033352
Gene Description: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
UniGene ID: Mm.22306