mouse ITGA2B shRNA silencing AAV

Cat. No: shAAV-262427

Availability: 6-8 weeks

Name: AAV-m-ITGA2B-shRNA

This is an AAV expressing shRNA for silencing of Mouse Itga2b.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Itga2b
Gene Name: integrin alpha 2b
Gene ID: 16399
Gene Synonyms: AI172977; alphaIIb; CD41; CD41B; GpIIb
ORF Size: 3102 bp
RefSeq#: NM_010575
Gene Description: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
UniGene ID: Mm.26646