mouse IL1R2 shRNA silencing AAV

Cat. No: shAAV-262139

Availability: 6-8 weeks

Name: AAV-m-IL1R2-shRNA

This is an AAV expressing shRNA for silencing of Mouse Il1r2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Il1r2
Gene Name: interleukin 1 receptor, type II
Gene ID: 16178
Gene Synonyms: CD121b; Il1r-2
ORF Size: 843 bp
RefSeq#: NM_010555
Gene Description: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
UniGene ID: Mm.1349