mouse IGF2R shRNA silencing AAV

Cat. No: shAAV-261968

Availability: 4-5 weeks

Name: AAV-m-IGF2R-shRNA

This is an AAV expressing shRNA for silencing of Mouse Igf2r.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Igf2r
Gene Name: insulin-like growth factor 2 receptor
Gene ID: 16004
Gene Synonyms: AI661837; CD222; CI-MPR; M6P/IGF2R; Mpr300
ORF Size: 7452 bp
RefSeq#: NM_010515
Gene Description: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
UniGene ID: Mm.26553