mouse GRIN2B shRNA silencing AAV

Cat. No: shAAV-260769

Availability: 6-8 weeks

Name: AAV-m-GRIN2B-shRNA

This is an AAV expressing shRNA for silencing of Mouse Grin2b.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Grin2b
Gene Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Gene ID: 14812
Gene Synonyms: AW490526; GluN2B; Nmdar2b; NR2B
ORF Size: 4446 bp
RefSeq#: NM_008171
Gene Description: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
UniGene ID: Mm.436649