mouse FPGS shRNA silencing AAV

Cat. No: shAAV-259611

Availability: 6-8 weeks

Name: AAV-m-FPGS-shRNA

This is an AAV expressing shRNA for silencing of Mouse Fpgs.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Fpgs
Gene Name: folylpolyglutamyl synthetase
Gene ID: 14287
Gene Synonyms: AA408187
ORF Size: 1638 bp
RefSeq#: NM_010236
Gene Description: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.
UniGene ID: Mm.3830