mouse FNBP1L shRNA silencing AAV

Cat. No: shAAV-259521

Availability: 6-8 weeks

Name: AAV-m-FNBP1L-shRNA

This is an AAV expressing shRNA for silencing of Mouse Fnbp1l.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Fnbp1l
Gene Name: formin binding protein 1-like
Gene ID: 214459
Gene Synonyms: 2610318I01Rik; AW548221; toca-1; TOCA1
ORF Size: 1116 bp
RefSeq#: NM_153118
Gene Description: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.
UniGene ID: Mm.470230