mouse FMR1 shRNA silencing AAV

Cat. No: shAAV-259506

Availability: 4-5 weeks

Name: AAV-m-FMR1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Fmr1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Fmr1
Gene Name: fragile X mental retardation syndrome 1
Gene ID: 14265
Gene Synonyms: Fmr-1; FMRP
ORF Size: 1845 bp
RefSeq#: NM_008031
Gene Description: Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).
UniGene ID: Mm.3451