mouse FAS shRNA silencing AAV

Cat. No: shAAV-259165

Availability: 4-5 weeks

Name: AAV-m-FAS-shRNA

This is an AAV expressing shRNA for silencing of Mouse Fas.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Fas
Gene Name: Fas (TNF receptor superfamily member 6)
Gene ID: 14102
Gene Synonyms: AI196731; APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6
ORF Size: 984 bp
RefSeq#: NM_007987
Gene Description: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
UniGene ID: Mm.1626