mouse FAIM3 shRNA silencing AAV

Cat. No: shAAV-258895

Availability: 6-8 weeks

Name: AAV-m-FAIM3-shRNA

This is an AAV expressing shRNA for silencing of Mouse Fcmr.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Fcmr
Gene Name: Fc fragment of IgM receptor
Gene ID: 69169
Gene Synonyms: 1810037B05Rik; Faim3; FcmuR; Toso
ORF Size: 1269 bp
RefSeq#: NM_026976
Gene Description: FAIM3 may play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
UniGene ID: Mm.46042