mouse EPAS1 shRNA silencing AAV

Cat. No: shAAV-258542

Availability: 6-8 weeks

Name: AAV-m-EPAS1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Epas1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Epas1
Gene Name: endothelial PAS domain protein 1
Gene ID: 13819
Gene Synonyms: bHLHe73; HIF-2alpha; HIF2A; HLF; HRF; MOP2
ORF Size: 2625 bp
RefSeq#: NM_010137
Gene Description: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
UniGene ID: Mm.1415