mouse EIF2S1 shRNA silencing AAV

Cat. No: shAAV-258193

Availability: 6-8 weeks

Name: AAV-m-EIF2S1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Eif2s1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Eif2s1
Gene Name: eukaryotic translation initiation factor 2, subunit 1 alpha
Gene ID: 13665
Gene Synonyms: 0910001O23Rik; 2410026C18Rik; 35kDa; Eif2a; eIF2alpha
ORF Size: 948 bp
RefSeq#: NM_026114
Gene Description: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
UniGene ID: Mm.196220