mouse E2F6 shRNA silencing AAV

Cat. No: shAAV-257659

Availability: 4-5 weeks

Name: AAV-m-E2F6-shRNA

This is an AAV expressing shRNA for silencing of Mouse E2f6.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: E2f6
Gene Name: E2F transcription factor 6
Gene ID: 50496
Gene Synonyms: AI462434; E2F6a; E2F6b; EMA
ORF Size: 819 bp
RefSeq#: NM_033270
Gene Description: Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F-6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
UniGene ID: Mm.23296