mouse DOCK3 shRNA silencing AAV

Cat. No: shAAV-257370

Availability: 6-8 weeks

Name: AAV-m-DOCK3-shRNA

This is an AAV expressing shRNA for silencing of Mouse Dock3.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Dock3
Gene Name: dedicator of cyto-kinesis 3
Gene ID: 208869
Gene Synonyms: mKIAA0299; MOCA; PBP
ORF Size: 6093 bp
RefSeq#: NM_153413
Gene Description: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of beta-amyloid APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity).
UniGene ID: Mm.150259