mouse DNAJC2 shRNA silencing AAV

Cat. No: shAAV-257306

Availability: 4-5 weeks

Name: AAV-m-DNAJC2-shRNA

This is an AAV expressing shRNA for silencing of Mouse Dnajc2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Dnajc2
Gene Name: DnaJ heat shock protein family (Hsp40) member C2
Gene ID: 22791
Gene Synonyms: AU020218; MIDA1; Zrf1; Zrf2
ORF Size: 1866 bp
RefSeq#: NM_009584
Gene Description: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.
UniGene ID: Mm.266312