mouse DICER1 shRNA silencing AAV

Cat. No: shAAV-257176

Availability: 4-5 weeks

Name: AAV-m-DICER1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Dicer1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Dicer1
Gene Name: dicer 1, ribonuclease type III
Gene ID: 192119
Gene Synonyms: 1110006F08Rik; D12Ertd7e; mKIAA0928
ORF Size: 5718 bp
RefSeq#: NM_148948
Gene Description: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs.
UniGene ID: Mm.21135