mouse DERL2 shRNA silencing AAV

Cat. No: shAAV-257099

Availability: 4-5 weeks

Name: AAV-m-DERL2-shRNA

This is an AAV expressing shRNA for silencing of Mouse Derl2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Derl2
Gene Name: Der1-like domain family, member 2
Gene ID: 116891
Gene Synonyms: CGI-101; Derlin-2; F-lana; Flana
ORF Size: 720 bp
RefSeq#: NM_033562
Gene Description: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.
UniGene ID: Mm.446351