mouse DCUN1D1 shRNA silencing AAV

Cat. No: shAAV-256876

Availability: 4-5 weeks

Name: AAV-m-DCUN1D1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Dcun1d1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Dcun1d1
Gene Name: DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
Gene ID: 114893
Gene Synonyms: pTes3; Rp42; SCCRO; Tes3
ORF Size: 780 bp
RefSeq#: NM_033623
Gene Description: Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).
UniGene ID: Mm.474495