mouse CRK shRNA silencing AAV

Cat. No: shAAV-256132

Availability: 4-5 weeks

Name: AAV-m-CRK-shRNA

This is an AAV expressing shRNA for silencing of Mouse Crk.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Crk
Gene Name: v-crk avian sarcoma virus CT10 oncogene homolog
Gene ID: 12928
Gene Synonyms: c-Crk; Crk-I; Crk-II; Crk-III; Crk3; CrkIII; Crko; p38
ORF Size: 615 bp
RefSeq#: NM_133656
Gene Description: The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
UniGene ID: Mm.280125