mouse CLOCK shRNA silencing AAV

Cat. No: shAAV-255683

Availability: 4-5 weeks

Name: AAV-m-CLOCK-shRNA

This is an AAV expressing shRNA for silencing of Mouse Clock.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Clock
Gene Name: circadian locomotor output cycles kaput
Gene ID: 12753
Gene Synonyms: 5330400M04Rik; KAT13D
ORF Size: 2568 bp
RefSeq#: NM_007715
Gene Description: ARNTL/2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate: ARNTL (By similarity). Plays a role in DNA damage response (DDR) signaling during the S phase.
UniGene ID: Mm.392894