mouse CIITA shRNA silencing AAV

Cat. No: shAAV-255507

Availability: 6-8 weeks

Name: AAV-m-CIITA-shRNA

This is an AAV expressing shRNA for silencing of Mouse Ciita.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Ciita
Gene Name: class II transactivator
Gene ID: 12265
Gene Synonyms: C2ta; EG669998; Gm9475; Mhc2ta
ORF Size: 3237 bp
RefSeq#: NM_007575
Gene Description: Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter.
UniGene ID: Mm.249560