mouse CABLES1 shRNA silencing AAV

Cat. No: shAAV-254346

Availability: 4-5 weeks

Name: AAV-m-CABLES1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Cables1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Cables1
Gene Name: CDK5 and Abl enzyme substrate 1
Gene ID: 63955
Gene Synonyms: Cables; ik3-1
ORF Size: 1707 bp
RefSeq#: NM_022021
Gene Description: Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).
UniGene ID: Mm.40717