mouse BRAP shRNA silencing AAV

Cat. No: shAAV-254068

Availability: 4-5 weeks

Name: AAV-m-BRAP-shRNA

This is an AAV expressing shRNA for silencing of Mouse Brap.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Brap
Gene Name: BRCA1 associated protein
Gene ID: 72399
Gene Synonyms: 3010002G07Rik; BRAP2; IMP
ORF Size: 1125 bp
RefSeq#: NM_028227
Gene Description: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
UniGene ID: Mm.153372