mouse BMI1 shRNA silencing AAV

Cat. No: shAAV-254009

Availability: 4-5 weeks

Name: AAV-m-BMI1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Bmi1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Bmi1
Gene Name: Bmi1 polycomb ring finger oncogene
Gene ID: 12151
Gene Synonyms: AW546694; Bmi-1; Pcgf4
ORF Size: 975 bp
RefSeq#: NM_007552
Gene Description: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
UniGene ID: Mm.289584