mouse BLOC1S1 shRNA silencing AAV

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Recombinant AAV

AAV-ITR

AAV2

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Gene Details

Species

Mouse

Gene Symbol

Bloc1s1

Gene Name

biogenesis of lysosomal organelles complex-1, subunit 1

Gene ID

14533

Gene Synonyms

AI839753; BLOS1; Gcn5l1

ORF Size

378 bp

RefSeq#

NM_015740

Gene Description

BLOC1S1 may negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5A1 AND NDUFA9. May also be involved in the biogenesis of specialized organelles of the endosomal-lysosomal system.

UniGene ID

Mm.30118