mouse BBS2 shRNA silencing AAV

Cat. No: shAAV-253659

Availability: 6-8 weeks

Name: AAV-m-BBS2-shRNA

This is an AAV expressing shRNA for silencing of Mouse Bbs2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Bbs2
Gene Name: Bardet-Biedl syndrome 2 (human)
Gene ID: 67378
Gene Synonyms: 2410125H22Rik; AI447581
ORF Size: 2166 bp
RefSeq#: NM_026116
Gene Description: The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.
UniGene ID: Mm.292107