mouse ATP5A1 shRNA silencing AAV

Cat. No: shAAV-253292

Availability: Immediate

Name: AAV-m-ATP5A1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Atp5a1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Atp5a1
Gene Name: ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1
Gene ID: 11946
Gene Synonyms: AI035633; AL022851; AL023067; Atpm; D18Ertd206e; Mom2
ORF Size: 1662 bp
RefSeq#: NM_007505
Gene Description: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).
UniGene ID: Mm.474505