mouse APC shRNA silencing AAV

Cat. No: shAAV-252807

Availability: 4-5 weeks

Name: AAV-m-APC-shRNA

This is an AAV expressing shRNA for silencing of Mouse Apc.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Apc
Gene Name: adenomatosis polyposis coli
Gene ID: 11789
Gene Synonyms: AI047805; AU020952; AW124434; CC1; mAPC; Min
ORF Size: 8529 bp
RefSeq#: NM_007462
Gene Description: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
UniGene ID: Mm.384171