mouse AKR1A4 shRNA silencing AAV

Cat. No: shAAV-252412

Availability: 4-5 weeks

Name: AAV-m-AKR1A4-shRNA

This is an AAV expressing shRNA for silencing of Mouse Akr1a1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Akr1a1
Gene Name: aldo-keto reductase family 1, member A1 (aldehyde reductase)
Gene ID: 58810
Gene Synonyms: 2610201A18Rik; Akr1a4
ORF Size: 978 bp
RefSeq#: NM_021473
Gene Description: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
UniGene ID: Mm.30085