mouse ITM2B shRNA silencing AAV

Cat. No: shAAV-252337

Availability: 4-5 weeks

Name: AAV-m-ITM2B-shRNA

This is an AAV expressing shRNA for silencing of Mouse Itm2b.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Itm2b
Gene Name: integral membrane protein 2B
Gene ID: 16432
Gene Synonyms: AI256040; Bri; Bri2; Bricd2b; D14Sel6; E25BMM; imBRI2
ORF Size: 801 bp
RefSeq#: NM_008410
Gene Description: Plays a regulatory role in the processing of the beta-amyloid A4 precursor protein (APP) and acts as an inhibitor of the beta-amyloid peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites|Function: Mature BRI2 (mBRI2) functions as a modulator of the beta-amyloid A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed beta-amyloid protein 40 and beta-amyloid protein 42|Function: Bri23 peptide prevents aggregation of APP beta-amyloid protein 42 peptide into toxic oligomers.
UniGene ID: Mm.4266