mouse ADIPOQ shRNA silencing AAV

Cat. No: shAAV-252146

Availability: 6-8 weeks

Name: AAV-m-ADIPOQ-shRNA

This is an AAV expressing shRNA for silencing of Mouse Adipoq.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Adipoq
Gene Name: adiponectin, C1Q and collagen domain containing
Gene ID: 11450
Gene Synonyms: 30kDa; Acdc; Acrp30; Ad; adipo; apM1; APN; GBP28
ORF Size: 744 bp
RefSeq#: NM_009605
Gene Description: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
UniGene ID: Mm.3969