mouse ABCA4 shRNA silencing AAV

Cat. No: shAAV-251762

Availability: 6-8 weeks

Name: AAV-m-ABCA4-shRNA

This is an AAV expressing shRNA for silencing of Mouse Abca4.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Abca4
Gene Name: ATP-binding cassette, sub-family A (ABC1), member 4
Gene ID: 11304
Gene Synonyms: Abc10; Abcr; AW050280; D430003I15Rik; RmP
ORF Size: 6933 bp
RefSeq#: NM_007378
Gene Description: In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.
UniGene ID: Mm.3918