mouse SIKE1 shRNA silencing AAV

Cat. No: shAAV-251370

Availability: 4-5 weeks

Name: AAV-m-SIKE1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Sike1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Sike1
Gene Name: suppressor of IKBKE 1
Gene ID: 66641
Gene Synonyms: 2810005O12Rik; 5730470L24Rik; AI450236; AI839862; Sike; Sikeb
ORF Size: 624 bp
RefSeq#: NM_025679
Gene Description: Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.
UniGene ID: Mm.208619