mouse 1200011M11RIK shRNA silencing AAV

Cat. No: shAAV-250183

Availability: 4-5 weeks

Name: AAV-m-1200011M11RIK-shRNA

This is an AAV expressing shRNA for silencing of Mouse Smg8.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Smg8
Gene Name: smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)
Gene ID: 74133
Gene Synonyms: 1200011M11Rik
ORF Size: 2976 bp
RefSeq#: NM_024262
Gene Description: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.
UniGene ID: Mm.23257