human DYX1C1 shRNA silencing AAV

Cat. No: shAAV-232660

Availability: 6-8 weeks

Name: AAV-h-DYX1C1-shRNA

This is an AAV expressing shRNA for silencing of Human DYX1C1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: DYX1C1
Gene Name: dyslexia susceptibility 1 candidate 1
Gene ID: 161582
Gene Synonyms: CILD25; DNAAF4; DYX1; DYXC1; EKN1; RD
ORF Size: 1146 bp
RefSeq#: NM_130810
Gene Description: DYX1C1 encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with estrogen receptors and the heat shock proteins, Hsp70 and Hsp90. An homologous protein in rat has been shown to function in neuronal migration in the developing neocortex. A chromosomal translocation involving this gene is associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits in reading and spelling. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream cell cycle progression 1 (CCPG1) gene.
UniGene ID: Hs.126403
HGNC ID: HGNC:21493