human DGCR8 shRNA silencing AAV

Cat. No: shAAV-232656

Availability: 6-8 weeks

Name: AAV-h-DGCR8-shRNA

This is an AAV expressing shRNA for silencing of Human DGCR8.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: DGCR8
Gene Name: DGCR8, microprocessor complex subunit
Gene ID: 54487
Gene Synonyms: C22orf12; DGCRK6; Gy1; pasha
ORF Size: 2223 bp
RefSeq#: NM_022720
Gene Description: DGCR8 encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants.
UniGene ID: Hs.643452
HGNC ID: HGNC:2847