human IRS1 shRNA silencing AAV

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Recombinant AAV

AAV-ITR

AAV2

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Gene Details

Species

Human

Gene Symbol

IRS1

Gene Name

insulin receptor substrate 1

Gene ID

3667

Gene Synonyms

HIRS-1

ORF Size

3729 bp

RefSeq#

NM_005544

Gene Description

IRS1 encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

UniGene ID

Hs.471508

HGNC ID

HGNC:6125