human IL24 shRNA silencing AAV

Cat. No: shAAV-230082

Availability: 6-8 weeks

Name: AAV-h-IL24-shRNA

This is an AAV expressing shRNA for silencing of Human IL24.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: IL24
Gene Name: interleukin 24
Gene ID: 11009
Gene Synonyms: C49A; FISP; IL10B; MDA7; MOB5; ST16
ORF Size: 624 bp
RefSeq#: NM_006850
Gene Description: IL24 encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
UniGene ID: Hs.719320
HGNC ID: HGNC:11346